Probing the Mechanism of Cyanobacterial Aldehyde Decarbonylase Using a Cyclopropyl Aldehyde
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چکیده
منابع مشابه
Oxygen-independent decarbonylation of aldehydes by cyanobacterial aldehyde decarbonylase: a new reaction of diiron enzymes.
The search for new biofuels has generated increased interest in biochemical pathways that produce hydrocarbons. Although hydrocarbons are simple molecules, the biosynthesis of molecules that lack any chemical functional groups is surprisingly challenging. Biochemical reactions that remove functionality, such as decarboxylations, dehydrations and reduction of double bonds, invariably rely on the...
متن کاملAldehyde dehydrogenase: kinetics and mechanism.
Blakley, R. L. (1985) in Folates and Pterins (Blakley, R. L. & Benkovic, S. J., eds.), vol. 1 , pp. 191 -253, Wiley, New York Bolin, J. T., Filman, D. J., Matthews, D. A., Hamlin, R. C. & Kraut, J. ( 1982) J. Biol. Chem. 257, 1365013662 Clore, G. M., Gronenborn, A. M., Birdsall, B., Feeney, J. & Roberts, G. C. K. ( 1984) Biochem. J. 2 17,659-666 Feeney, J. (1986) in NMR in Living Systems (Axenr...
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Bovine lens cytoplasmic aldehyde dehydrogenase exhibits Michaelis-Menten kinetics with acetaldehyde, glyceraldehyde 3-phosphate, p-nitrobenzaldehyde, propionaldehyde, glycolaldehyde, glyceraldehyde, phenylacetylaldehyde and succinic semialdehyde as substrates. The enzyme was also active with malondialdehyde, and exhibited an esterase activity. Steady-state kinetic analyses show that the enzyme ...
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Parkinson disease (PD) is a neurodegenerative disorder particularly characterized by the loss of dopaminergic neurons in the substantia nigra. Pesticide exposure has been associated with PD occurrence, and we previously reported that the fungicide benomyl interferes with several cellular processes potentially relevant to PD pathogenesis. Here we propose that benomyl, via its bioactivated thioca...
متن کاملAldehyde dehydrogenase. Covalent intermediate in aldehyde dehydrogenation and ester hydrolysis.
4-trans-(NN-Dimethylamino)cinnamaldehyde (an aldehyde, DACA) and 4-trans-(NN-dimethylamino)cinnamoylimidazole (an amide, DACI) have been shown to be substrates for human aldehyde dehydrogenase (EC 1.2.1.3) which form chromophoric covalent intermediates. The spectra of covalent intermediates from both the cytoplasmic (E1) and mitochondrial (E2) isoenzymes derived from DACA and DACI were compared...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2013
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja3115949